- As T3 goes up, cortisol is supposed to go up, too.
- Since Cortisol is directly synthesized from progesterone in the adrenal cortex, it makes sense that as a woman's T3 amounts go and adrenals respond with more cortisol, her body would need to make more progesterone to be able to synthesize that cortisol.
- Progesterone is made from pregnenolone, but it is secreted from the corpus luteum.
- (*This is important information for women who have had their ovaries removed! They MUST have progesterone replaced in their bodies.)
- So, as the need for more cortisol rises with the rise in T3, so did would the need for more progesterone. This is important for any woman who is on progesterone replacement for whatever reason; theoretically, she would need more progesterone as she progresses with CT3M.
Also, I think we might need progesterone for the conversion of T4 to T3? Can't remember.
Finally, keeping in mind that cortisol assists with/affects:
Raising the BP
Blood sugar regulation